Popular heartburn drugs may increase esophageal cancer risk
Drugs such as Nexium, Prilosec and Prevacid that control production of stomach acid and treat heartburn, reflux, peptic ulcers and related conditions are some of the most popular medications on the market.
But long-term use of these drugs, known as proton pump inhibitors, can have unexpected consequences, a new study shows.
Blair A. Jobe and his research team at the University of Pittsburgh School of Medicine say the severity of symptoms for GERD, or gastroesophageal reflux disease, has an inverse relationship with the presence of Barrett's esophagus, a precursor to a lethal form of esophageal cancer known as adenocarcinoma.
The concern is that successful control of symptoms does not reduce cancer risk but actually increases it.
The study, published online by the journal Archives of Surgery, also raises questions whether proton pump inhibitors might cause the cancer, whose incidence per million has risen sixfold from 1975 to 2001, a time when PPIs came on the market with increasing use. It's the fastest growing cancer in the nation, outpacing melanoma, breast and prostate cancers.
In the Pitt study, patients taking PPIs who reported no severe GERD symptoms had significantly higher odds of having esophageal cancer as compared with medically treated patients who reported severe symptoms.
This finding, it says, may explain the failure of current screening procedures that dictate when primary endoscopic examinations are done. Those exams that involve a scope to inspect the esophagus usually are prescribed based on symptom severity. Dr. Jobe said only 5 percent of patients who develop esophageal adenocarcinoma are detected by screening efforts, with the remaining 95 percent having symptoms related to a more advanced and less curable cancer stage.
Doing a screening endoscopy on patients with GERD even for those without severe symptoms, might be a wise choice, the study concludes, because PPI medications could be masking the severity of the problem.
In the study, an increasing number of severe GERD symptoms actually were associated with decreased odds of esophageal cancer. Those taking PPIs proved to be 61 percent more likely to have Barrett's esophagus or cancer if they reported no typical GERD symptoms of heartburn, regurgitation and difficulty swallowing or dysphagia, with 81.5 percent more likely to have the cancer if they reported atypical GERD symptoms of throat-clearing, excess mucus, "lump in the throat" sensation or cough. Those high rates are in comparison with people using PPIs who reported severe symptoms.
Hiatus Hernia Diet - News
concerns doctors about risk factors, many of which include symptom duration, diet, Caucasian race, male, older age and having GERD with the presence of a hiatal hernia, a condition where the top portion of the stomach has migrated into the chest.
"My patients have been extremely pleased to return to a normal diet and lifestyle," explains Gracias. "They also like the fact that they don't have to return for a second surgery." "EsophyX is a great solution for my reflux and hiatal hernia patients
concerns doctors about risk factors, many of which include symptom duration, diet, Caucasian race, male, older age and having GERD with the presence of a hiatal hernia, a condition where the top portion of the stomach has migrated into the chest.
There can be a number of causes: hormonal changes and increased pressure on this valve during pregnancy; obesity; a rich diet; or a hiatus hernia. For most sufferers, symptoms are improved with lifestyle changes, such as eating smaller meals,
However, if your GERD is due to a hiatal hernia, this could be repaired at the same time that your band is placed and your GERD could potentially be cured. Gastric bypass surgery is an anti-reflux surgery and in many cases can cure GERD.
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Hiatus Hernia refers to the displacement of a portion of the stomach through the opening in the diaphragm, through which the esophagus passes from che
Hiatus Hernia Diet - HealthCentral
Everything you need to know about hiatus hernia diet, including common uses, side effects, interactions and risks.
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A hiatus hernia, aka hiatal hernia, is when part of your stomach bulges out through your diaphragm at your hiatus, which is where your esophagus passes through. ...
Diet Control for Hiatus Hernia
When the esophageal opening, also called diaphragmatic hiatus, becomes weaker, the upper part of the stomach is allowed to push through and reach the chest cavity.