Neuroblastoma In Children – New Treatment For Childhood Neuroblastoma Revealed
. The study tested the principle that combined positron emission tomography and X-ray computed tomography (PET/CT) may be used to select children with primary refractory or relapsed high-risk neuroblastoma for treatment with a molecular radiotherapy known as 177Lu-DOTATATE. This therapeutic option was found to be viable option for children with neuroblastomas.Neuroblastoma is a cancerous tumor that develops from nerve tissue in infants and children. Accounting for six to 10 percent of all childhood cancers, it does not always follow the same pattern, with some patients regressing spontaneously and other progressing, despite aggressive therapy. The long-term survival rate for neuroblastoma is below 40 percent.
“We know that peptide receptor radionuclide therapy in adults with somatostatin-positive neuroendocrine tumors has resulted in improved symptoms, prolonged survival and an enhanced quality of life. Since some neuroblastomas express somatostatin receptors, we felt this approach could be beneficial to children as well,” said Jamshed B. Bomanji, MBBS, PhD, FRCR, FRCP, one of the authors of the study “177Lu-DOTATATE Molecular Radiotherapy for Childhood Neuroblastoma.”
In the study, eight children with relapsed or primary refractory neuroblastoma were imaged with a 68Ga-DOTATATE PET/CT scan. If the disease sites showed 68Ga-DOTATATE uptake greater than the liver, the child was considered eligible for the molecular radiotherapy. Therapy with 177Lu-DOTATATE was determined to be suitable for six of the children and was administered appropriately.
After completing treatment with 177Lu-DOTATATE, five children had stable disease by the response evaluation criteria in solid tumors. The treatment was feasible, practical and well-tolerated in the small group of patients with high-risk neuroblastoma. As a result, the researchers plan to evaluate 177Lu-DOTATATE formally in a phase I-II clinical trial to evaluate toxicity and response.
“Molecular imaging has contributed a new diagnostic technique to map the full extent of disease. This mode of treatment has great potential for children whose treatment options are limited, as neuroblastoma often becomes resistant to chemotherapy and success is limited by poor bone marrow reserve,” noted Bomanji.
About SNM—Advancing Molecular Imaging and Therapy
SNM is an international scientific and medical organization dedicated to raising public awareness about what molecular imaging is and how it can help provide patients with the best health care possible. SNM members specialize in molecular imaging, a vital element of today’s medical practice that adds an additional dimension to diagnosis, changing the way common and devastating diseases are understood and treated.
Journal Of Nuclear Medicine - News
The Society of Nuclear Medicine has picked its 2011 Image of the Year, published in the Journal of Nuclear Medicine's August 1 edition. The image, courtesy of radiologists at Stanford University and Hospital Mãe de Deus in
(PET) scans using F-18 florbetaben (18F-FDG) are more reliable than traditional neuropsychological testing in tracking the evolution of mild cognitive impairment to Alzheimer's disease, researchers reported in the Journal of Nuclear Medicine.
A new treatment option may soon be available for children with neuroblastoma according to research published in the July issue of The Journal of Nuclear Medicine. The study tested the principle that combined positron emission tomography and X-ray
A retrospective study of 1301 US nuclear cardiology labs applying for accreditation by the Intersocietal Commission for the Accreditation of Nuclear Medicine Laboratories (ICANL) found that 57% were noncompliant with at least one of 18 required
JVIR published 275 articles in 2010, earning 5900 citations among radiology, nuclear medicine and medical imaging journals and peripheral vascular disease journals. The journal's continued excellence is the result of the efforts of the current
Child-specific doses for pediatric PET individuals | Health ...
(JNM), scientists on the youngsters’s Hospital of Philadelphia (CHOP) as well as the college of Pennsylvania (Penn) gathered info that may perhaps supply clinicians with new formulas — particular to pediatrics — to calculate the sum of radiotracer that need to be injected based mostly about the individual’s pounds.
"These findings indicate that PET — an extremely popular nuclear medication treatment — is usually made use of in youngsters with strategies that happen to be a lot more patient-specific than these at the moment employed," mentioned Roberto Accorsi, Ph.D., previous study assistant professor of radiology at CHOP-Penn and lead writer with the examine.
This examine is a person extra contribution on the professional medical imaging group’s total efforts to lower radiation dose to youngsters. Nuclear medication professionals are constantly refining methodologies as a way to protect picture top quality and decrease radiation publicity for the duration of pediatric PET exams. due to the fact professional medical study printed recently highlights the overall health dangers of publicity to ionizing radiation, numerous have seemed on the professional medical group for strategies to curb publicity for the duration of professional medical imaging exams. even though the nuclear medication exam’s rewards on the individual much outweigh any possible dangers connected with radiation, the nuclear medication group seeks to uphold methods that happen to be constant and mindful of individuals’ considerations.
In nuclear medication, you will find well-established suggestions for administering radiopharmaceutical doses for adults; even so, you can find minor advice for administering pediatric doses. as a result, the CHOP-Penn examine sets out to study how nuclear medication doctors can consider into consideration a boy or girl’s lighter pounds and system measurement and regulate the dose and scan time accordingly, though retaining high-quality imaging for your finest prognosis feasible.
Image top quality for PET is dependent strongly about the individual’s pounds and system make. to put it differently, the greater and heavier the individual, the extra injection dose or probably a lengthier scan time is required to acquire a top quality picture. For individuals who’re lighter and also have much less system mass — like as in pediatric individuals — much less injection dose or even a lowered scan time may perhaps even now let for high-quality photographs.
Laboratory of Neuro Imaging : Evidence-Based Imaging in Pediatrics - Journal of Nuclear Medicine (subscription) 
Nuclear medicine may detect Alzheimer's early, identify remedies, guide prevention: Study 
RT @: 's Journal of Nuclear Medicine Research Supports Upcoming Alzheimer's Disease Guidelines: "We urgently... 
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's Journal of Nuclear Medicine Research Supports Upcoming Alzheimer's Disease Guidelines: "We urgently... Journal Of Nuclear Medicine - Bookshelf
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